BT8305 CELL Biology lecture Notes Syllabus Book
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BT8305 CELL BIOLOGY
UNIT I CELL STRUCTURE AND FUNCTION OF THE ORGANELLES
Prokaryotic, Eukaryotic cells, Sub-cellular organelles and
functions. Principles of membrane
organization membrane proteins, cytoskeletal proteins. Extra
cellular matrix, cell-cell junctions.
UNIT II CELL DIVISION, CANCER, APOPTOSIS AND IMMORTALIZATION
OF CELLS
Cell cycle – Mitosis, Meiosis, Molecules controlling cell
cycle, cancer, role of Ras and Raf in
oncogenesis and apoptosis. Stem cells, Cell culture and
immortalization of cells and its
applications.
UNIT III TRANSPORT ACROSS CELL MEMBRANE
Passive and Active Transport, Permeases, Ion channels, ATP
pumps. Na+ / K+ / Ca+2Tpumps,
uniport, symport antiporter system. Ligand gated / voltage
gated channels, Agonistsand
Antagonists.
UNIT IV SIGNAL TRANSDUCTION
Receptors – extracellular signaling, Cell surface /
cytosolic receptors and examples,
Differentclasses of receptors antocrine / paracrine /
endocrine models, Secondary messengers
molecules.
UNIT V TECHNIQUES USED TO STUDY CELLS
Cell fractionation and flow cytometry, Morphology and
identification of cells using microscopic
studies like SEM, TEM and Confocal Microscopy. Localization
of proteins in cells –
Immunostaining.
TEXT BOOKS:
1. Lodish, Harvey etal., “Molecular Cell Biology”, 7 th Edition, W.H.Freeman, 2005.
2. Cooper, G.M. and R.E. Hansman “The Cell: A Molecular
Approach”, VIIth Edition, ASM Press, 2007.
3. Alberts, Bruce etal., “Molecular Biology of the Cell”, IVth
Edition, Garland Science (Taylors Francis), 2002.
4. Sadava, D.E. “Cell Biology: Organelle Structure and
Function”, Panima Publishing, 2004.
5. Rastogi, S.C. “Cell Biology” IInd Edition, New Age
International, 2002.
REFERENCES:
1. Becker, W.M. etal., “The World of the Cell”, 9 th Edition, Pearson Education, 2003.
2. Campbell, N.A., J.B. Recee and E.J. Simon “Essential
Biology”, VIIrd Edition, Pearson
International, 2007.
3. Alberts, Bruce etal., “Essential Cell Biology”, IV th Edition, Garland Press (Taylor & Francis),
2004.
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