BT8304 BIOORGANIC CHEMISTRY Notes Syllabus Question Bank Regulation 2017

 BT8304 BIOORGANIC CHEMISTRY  Lecture Notes Syllabus Book Previous  2 13 15 Marks  Anna University Important Question Bank With Answers  Regulation 2017 Study Materials Pdf Ppt

BT8304 BIOORGANIC CHEMISTRY

UNIT I BONDING AND STEREOCHEMISTRY 

Atoms Electrons and orbitals - Covalent Bonds - Octet rule - Polar covalant Bonds - lectronegativity- formal charge - Resonance Acids and Bases - Arrhenius and Bronsted Lowry Theories - Acid Base equilbria - SP3 hybridization - Conformations analysis ethane, butane and cyclohexane - Cis- trans isomerism. Stereochem activity around the tetrahedral c arbon – optical activity - Conformation of the peptide bond.

UNIT II MECHANISMS OF SUBSTITUTION AND ADDITION REACTIONS 

SN1 and SN2 reactions on tetrahedral carbon- nucleophiles- mechanism steric effects – nucleophilic addition on Acetals and ketals -Aldehyde and ketone groups – reactions of carbonyl group with amines- acid catalyzed ester hydrolysis – Saponification of an ester- hydrolysis of amides. Ester enolates - claisen .condensation – Michael condensation.

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UNIT III KINETICS AND MECHANISM 

Kinetic method – Rate law and mechanism – Transition states- Intermediates – Trapping of intermediates – Microscopic reversibility – Kinetic and thermodynamic reversibility – Isotopes for detecting intermediates. Primary and secondary isotopes – the Arrhenius equation Eyring equation

- ΔG, ΔS, ΔH, Thermodynamics of coupled reactions.

UNIT IV CATALYSIS 9

Reactivity – Coenzymes – Proton transfer – metal ions – Intra molecular reactions – Covalent atalysis – Catalysis by organized aggregates and phases. Inclusion complexation

UNIT V BIOORGANIC REACTIONS 9

Timing of Bond formation and fission – Acyl group transfer – C-C bond formation and fission –Catalysis of proton transfer reactions – Transfer of hydride ion – Alkyl group. Transfer – Terpene

biosynthesis – Merrifield state peptide synthesis – Sanger method for peptide and DNA

sequencing

TEXT BOOKS:

1. Carey, Francis A.” Organic Chemistry”. VIIth Edition, Tata MCGraw Hill, 2009.

2. Page, M.I. and Andrew Williams “Organic and Bio-organic Mechanisms”. Pearson, 2010.

REFERENCE:

1. Dugas, Hermann “ Bioorganic Chemistry: A Chemical Approach to Enzyme Action” 3rd

Edition, Springer, 2003.

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